Glycolide - 1,4-dioxane-2,5-dione - Cas 502-97-6

Glycolide, a key monomer in the synthesis of biodegradable and biocompatible polymers, has been extensively studied for its applications in medical devices and drug delivery systems. Recent research has focused on enhancing the properties and applications of glycolide-based polymers.

A comprehensive review published in 2020 discusses the synthesis and chemical transformations of glycolide and lactide as monomers for biodegradable polymers. This study highlights the versatility of these monomers in creating high-molecular-weight, degradation-prone polyesters suitable for medical, pharmaceutical, and food industry applications.

Another study explores the biocompatibility of poly(lactic-co-glycolic acid) (PLGA)-based polymer films. The findings indicate that these films are biocompatible, promoting cell growth and faster formation of cell layers compared to traditional culture methods. This suggests potential for PLGA-based materials in tissue engineering and regenerative medicine.

Additionally, the U.S. Food and Drug Administration (FDA) has investigated the effect of solvent isomeric structures on the dissolution of PLGAs with varying lactide:glycolide ratios. This research aims to optimize the formulation and processing of PLGA-based materials for medical applications, ensuring consistent performance and safety.